Work in the Nalepa laboratory aims to mechanistically dissect origins of abnormal cell division, genomic instability and cancer in the bone marrow failure syndrome Fanconi anemia (FA), Barth syndrome and other childhood bone marrow failure/cancer predisposition syndromes. Our research is funded by the NIH R01, St. Baldrick’s Foundation and Riley Children’s Foundation.
Available projects include discovery and mechanistic characterization of novel FA-interacting cell cycle regulators using our new preclinical model of leukemia in FA, characterization of the first patient-specific model of Barth syndrome, and characterization of a novel tumor suppressor mouse knockout model. This is an opportunity to master a wide variety of research strategies while establishing an academic career to be highly competitive for a future tenure-track faculty appointment. Research techniques established in our lab include: cell cycle to super-resolution (SR-SIM), live and deconvolution microscopy, functional genomics (large-scale shRNA screening), bioinformatics analysis of whole-exome sequencing and RNAseq in humans and mice, and animal models of human disease. We invite applications from PhD and MD/PhD scientists. Candidate requirements include a high degree of interest and self-motivation to succeed in research, track record of outstanding scientific accomplishments evidenced by publication in peer-reviewed journals, and ability to work independently and within a team with excellent communication and writing skills. Experience in cell cycle, mouse model of human disease and super-resolution/deconvolution microscopy is advantageous.
Please submit a cover letter and a CV including list of publications with your application.